Antisense DNA and RNA: progress and prospects.
نویسندگان
چکیده
منابع مشابه
Antisense DNA and RNA: progress and prospects.
Using antisense DNA or RNA fragments to block the expression of selected genes, and thereby assess their function, is a powerful new tool for the molecular biolo gist. It is an approach that promises to be particularly useful in higher eukaryotes, where the genetic tools ap plicable to yeast and bacteria are not available. There are also obvious therapeutic implications in the use of antisens...
متن کاملAntisense DNA and RNA: progress and prospects
Using antisense DNA or RNA fragments to block the expression of selected genes, and thereby assess their function, is a powerful new tool for the molecular biolo gist. It is an approach that promises to be particularly useful in higher eukaryotes, where the genetic tools ap plicable to yeast and bacteria are not available. There are also obvious therapeutic implications in the use of antisens...
متن کاملAntisense DNA and RNA agents against picornaviruses.
Anti-picornaviral antisense agents are part of a broader group of nucleic acid-based molecules developed for sequence-specific inhibition of translation and/or transcription of the target sequence through induced nuclease activity or physical hindrance. Three types of nucleic acid-based gene silencing molecules can be distinguished, including DNA-base antisense oligonucleotides (ASO), nucleic a...
متن کاملRNA-based therapeutics: current progress and future prospects.
Recent advances of biological drugs have broadened the scope of therapeutic targets for a variety of human diseases. This holds true for dozens of RNA-based therapeutics currently under clinical investigation for diseases ranging from genetic disorders to HIV infection to various cancers. These emerging drugs, which include therapeutic ribozymes, aptamers, and small interfering RNAs (siRNAs), d...
متن کاملDNA Watermarking of Infectious Agents: Progress and Prospects
1 Department of Surgery, Scott & White Memorial Clinic and Hospital, Temple, Texas, United States of America, 2 Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, United States of America, 3 Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center College of Medicine, College Station, Texas, United States of America, 4 Department of P...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes & Development
سال: 1988
ISSN: 0890-9369
DOI: 10.1101/gad.2.5.502